Bioavailability Enhancement: When to Use Hot- Melt Extrusion versus Spray Drying

August 2, 2012

Enhancing bioavailability can be achieved through hot-melt extrusion (HME) or spray drying. The drug product's API properties and stage of development are important factors to consider when deciding which technique to use. There are also considerations to be made with regard to process, time and cost. To gain perspective on these issues as well as insight into more recent advances in HME and spray drying, Pharmaceutical Technology Europe (PTE) spoke to Bend Research, an independent drug-formulation development company.